A businessman sinks $200 million into a special project to help fight brain cancer. As part of this project, medical biologist Susan McAlester rather naughtily figures out a way to genetically enlarge shark brains, so that cancer-battling enzymes can be harvested. However, the shark subjects become super smart and decide they don't much like being cooped up in pens and being stabbed withhypodermics, so they figure a way to break out and make for the open sea...
